BACKGROUND:Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs).Many of the OSCCs present at late stages with an exceptionally poor prognosis.A probable limitation in management of patients with OSCC lies in the insufficient knowledge pertaining to the linkage between copy number alterations in OSCC and oral tumourigenesis
Transdermal administration of drugs is generally limited by the barrier function of the skin.Vesicular systems are one of the most controversial methods for transdermal delivery of active substances.The interest bridle and breastplate in designing transdermal delivery systems was relaunched after the discovery of elastic vesicles like transferosome
Abstract Microbes live within complex communities of interacting populations, either free-living in waters and soils or symbionts of animals and plants.Their interactions include the production Bread of antimicrobial peptides (bacteriocins) to antagonize competitors, and these producers must carry their own immunity gene for self-protection.Whether
Degeneration of the retinal pigment epithelium (RPE) plays a central role in age-related macular degeneration (AMD).Throughout life, RPE cells are challenged by a variety of cytotoxic stressors, some of which are cumulative with age and may ultimately contribute to drusen and lipofuscin accumulation.Stressors such as these continually damage RPE ce
3-nitro-1,2,4-tri-azol-5-one (NTO) is a high energy insensitive explosive.To study the shock initiation process of NTO-based polymer bonded explosive JEOL-1 (32%octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), 32% NTO, 28% Al and 8% binder system), the cylinder test, the gap experiments and numerical simulation were carried out.Firstly, we g